Letter: Leukemic meningitis in acute leukemic adults

Letter: Leukemic meningitis in acute leukemic adults.

Overexpression of microRNA-630 in Acute Leukemic T-cell line

Background: MicroRNAs (miRNAs) are noncoding RNAs that control the expression of their target mRNAs. It affects cancer cell proliferation and apoptosis as oncogenes or tumor suppressors. Dysregulation of miRNAs expression leads to the development of various cancers. Therefore, for the first time in this field, this study investigated the effect of overexpression of microRNA-630 on the Jurkat ce...

Leukemic meningitis in a patient with B-cell prolymphocytic leukemia.

(48.55 g/L) was detected. She received treatment with three courses of chlorambucil and prednisone and responded well. On current admission blood cell counts were as follows: hematocrit 22%, leukocytes 71.37310/L (5% neutrophils, 92% lymphocytes with lymphoplasmacytic appearance), platelets 66310/L. IgM paraprotein level was 60 g/L. Immunophenotype of the leukemic population gave the following ...

Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia

Background: Wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. Wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies. Objective: To investigate the expression profile of a large number of Wnt genes in leukemic cells from Iranian patients ...

Diagnosis and Management of Leukemic and Lymphomatous Meningitis.

BACKGROUND Leukemic and lymphomatous meningitis is a major presentation of primary or secondary central nervous system (CNS) involvement by aggressive lymphomas or acute leukemia. METHODS The medical literature and ongoing clinical trials were reviewed on the clinical presentation, diagnosis, prognosis, prevention, and treatment of leukemic and lymphomatous meningitis. RESULTS Treatment for...